The Journal of Experimental Medicine, Vol 84, 377-386,
Copyright, 1946, by The Rockefeller Institute for Medical Research New York
STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA
:
III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY
W. Barry Wood Jr. M.D.1,
Charlotte McLeod D.Sc.1, and
Edwin N. Irons M.D.1
1 From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore
The phagocytosis which occurs in the lungs of rats receiving sulfonamide is due neither to an opsonizing action of the sulfonamides nor to type-specific antibody. The evidence presented indicates that the destruction of the pneumococci is brought about by a phagocytic mechanism independent of both opsonization and capsular injury.
Submitted on June 9, 1946