The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 748K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saslaw, S.
Right arrow Articles by Schwab, J. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Saslaw, S.
Right arrow Articles by Schwab, J. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 84, 113-125, Copyright, 1946, by The Rockefeller Institute for Medical Research New York

ARTICLE

REACTIONS OF MONKEYS TO EXPERIMENTALLY INDUCED INFLUENZA VIRUS A INFECTION : AN ANALYSIS OF THE RELATIVE RÔLES OF HUMORAL AND CELLULAR IMMUNITY UNDER CONDITIONS OF OPTIMAL OR DEFICIENT NUTRITION



Samuel Saslaw M.D.1, H. E. Wilson M.D.1, Charles A. Doan M.D.1, O. C. Woolpert M.D.1, and J. L. Schwab Ph.D.1

1 From the Departments of Bacteriology and Medicine, The Ohio State University, Columbus

1. Macaca mulatta monkeys on a normal diet have proved resistant to intranasal but not to intratracheal inoculation of influenza virus.

2. Neutralizing antibodies appeared 8 to 10 days after inoculation with either living or heat-inactivated virus. The antibodies were noted to be still present as long as 9 months after infection with living virus.

3. A specific granulopenic leucopenia characteristically followed primary influenza virus inoculation, regardless of altered conditions of diet, exposure, and route of inoculation, but it was not observed in monkeys previously infected with the same virus, all of which invariably survived.

4. Nutritional deficiency and exposure to cold increased the susceptibility of monkeys on intranasal instillation of the virus; the leucopenia was profound and fatalities frequently occurred even though neutralizing humoral antibodies developed as promptly and in relatively the same titer as under optimum nutritional conditions.

 Submitted on April 2, 1946


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS