The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 83, 321-328, Copyright, 1946, by The Rockefeller Institute for Medical Research New York

ARTICLE

MOUSE-PROTECTIVE TITERS OF SERA OF VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES

Annabel W. Walter 1, Edna L. Schenkein 1, and Wheelan D. Sutliff M.D.1

1 From the Bureau of Laboratories of the Department of Health of the City of New York, New York

1. Sera of human subjects immunized with pneumococci or their type-specific polysaccharides showed type-specific antibody by mouse protection tests as well as on determinations of the specifically precipitable nitrogen.

2. The ratio, mouse-protective units to antibody nitrogen, was less in human sera of low potency than in more potent human or animal sera.

 Submitted on December 12, 1945


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