The Journal of Experimental Medicine, Vol 83, 295-301,
Copyright, 1946, by The Rockefeller Institute for Medical Research New York
COLORADO TICK FEVER AND DENGUE
:
AN EXPERIMENTAL IMMUNOLOGICAL AND CLINICAL COMPARISON
Lloyd Florio M.D.1,
William McD. Hammon M.D.1,
Angela Laurent 1, and
Mabel O. Stewart 1
1 From the George Williams Hooper Foundation for Medical Research, University of California, San Francisco, and the Department of Public Health and Laboratory Diagnosis, University of Colorado School of Medicine, Denter
Six human beings were inoculated with dengue and developed typical disease. Two of these were reinoculated and proved immune. The remaining four were later inoculated with Colorado tick fever. Three developed typical disease. The fourth, who remained well, has previously lived in an endemic area (Colorado). One patient was inoculated with Colorado tick fever first and later with dengue. He developed both diseases.
Colorado tick fever and dengue do not give a cross-immunity.
Hamsters can be infected with Colorado tick fever but not with dengue.
Colorado tick fever and dengue appear to be distinct disease entities.
Submitted on December 10, 1945
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