The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 83, 133-146, Copyright, 1946, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON SCRUB TYPHUS : I. SOLUBLE ANTIGEN IN TISSUES AND BODY FLUIDS OF INFECTED MICE AND RATS



Joseph E. Smadel M.D., Lieutenant Colonel1, Fred L. Rights Captain1, and Elizabeth B. Jackson Civilian Technician1

1 From the Division of Virus and Rickettsial Diseases, Army Medical School, Washington, D. C.

A complement-fixing antigen specific for scrub typhus occurs in the body fluids and tissues of infected mice, white rats, and cotton rats.

The specific serological substance is demonstrable only in those animals which develop a rapidly fatal disease after an incubation period of a few days. Such an experimental infection is induced in mice and rats by the intravenous injection of suspensions of yolk sac rich in R. orientalis.

Ether extraction is an important step in the preparation of a complement-fixing antigen from tissues of mice dying with scrub typhus.

The Imphal No. 8 and Calcutta strains of R. orientalis are indistinguishable on the basis of complement fixation and cross-immunity tests.

The complement-fixing antigen in body fluids of infected mice and rats and in our preparations of tissues from such animals occurs as a soluble antigen. Under the proper conditions the soluble antigen can be stored or dehydrated without loss of serological activity.

 Submitted on November 12, 1945


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