The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 82, 445-465, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES

Colin M. MacLeod M.D.1, Richard G. Hodges M.D. Captain1, Michael Heidelberger Ph.D.1, and William G. Bernhard M.D. Major1

1 From the Department of Bacteriology, New York University College of Medicine, New York, The Army Air Force Rheumatic Fever Control Program, Office of The Air Surgeon, and the Department of Medicine, College of Physicians and Surgeons of Columbia University, New York

1. Immunization of man with 0.03 to 0.06 mg. of each of the capsular polysaccharides of pneumococcus types I, II, V, and VII, given in a single subcutaneous injection, has been shown to be effective in preventing pneumonia caused by these types but not that due to heterologous types.

2. Immunity appears within a period of 2 weeks following injection of the polysaccharides. Its duration was not determined, although 6 months can be set as a minimum.

3. Immunization of alternate subjects in the population reduced greatly the incidence of pneumonia in the non-immunized.

4. The carrier rate for pneumococcus types I, II, V, and VII was lowered significantly in the immunized group as compared with the controls. It is suggested that an over-all reduction in the incidence of carriers was responsible for the lowered rates for pneumococcal pneumonia in the non-immunized group.

 Submitted on September 10, 1945


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