The Journal of Experimental Medicine, Vol 82, 375-383,
Copyright, 1945, by The Rockefeller Institute for Medical Research New York
THE INFLUENCE OF CHOLINE, CYSTINE, AND OF 
-TOCOPHEROL UPON THE OCCURRENCE OF CEROID PIGMENT IN DIETARY CIRRHOSIS OF RATS
Joseph Victor M.D.1 and
Alwin M. Pappenheimer M.D.1
1 From the Research Service, First (Columbia University) Division, Goldwater Memorial Hospital, Department of Hospitals, and the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York
1. Five per cent l-cystine in a stock or low protein diet produces ceroid deposits in rat liver. This effect of l-cystine is much greater in low protein than in stock diets.
2. One per cent choline has an inhibiting effect on deposition of liver ceroid resulting from a low protein diet containing excess cystine.
3. The occurrence of ceroid pigment in the livers of rats on a low protein diet, with or without the addition of excess l-cystine, is transiently inhibited by the administration of 
-tocopherol. Five per cent cod liver oil in the diet did not prevent this effect of -tocopherol.
4. On low protein, vitamin E-deficient diets, there occurs after 4 months, a rapid and progressive weight loss. This does not happen when -tocopherol is added to the diet.
Submitted on August 18, 1945
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