The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 82, 133-142, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE CHEMICAL ALTERATION OF A BACTERIAL SURFACE, WITH SPECIAL REFERENCE TO THE AGGLUTINATION OF B. PROTEUS OX-19

Seymour S. Cohen Ph.D.1

1 From the Eldridge Reeves Johnson Foundation for Medical Physics, The School of Medicine, University of Pennsylvania, and The Children's Hospital of Philadelphia, Philadelphia

The chemical substitution of a bacterial surface has been effected by the addition of benzene sulfonyl chloride to B. proteus OX-19. The substitution of imidazole and amino groups on the bacteria has been followed by the microelectrophoretic method. Concomitant changes in the agglutinability of substituted organisms have been observed, without appreciable change in the antibody-combining capacities of the organisms. The significance of these observations has been discussed.

Submitted on April 24, 1945


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