The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 82, 41-63, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR

Ian MacKenzie M.D.1 and John G. Kidd M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A detailed study has been made of an antibody which appears in the blood of certain rabbits implanted with the Brown-Pearce carcinoma or injected with extracts of it and which reacts specifically in vitro in mixture with a distinctive sedimentable constituent of the Brown-Pearce tumor cell. The observations as a whole seem to indicate that this constituent of the Brown-Pearce tumor differs notably from certain other sedimentable substances which can be extracted from various rabbit tissues and identified by serological means. The implications of the findings are discussed.

Submitted on March 21, 1944


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