The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 81, 349-358, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : III. ANTIBODY RESPONSE IN MAN FOLLOWING THE ADMINISTRATION OF THE SPECIFIC ANTIGEN OF TYPE V SHIGELLA PARADYSENTERIAE (FLEXNER)



Ely Perlman M.D.1, Francis Binkley Ph.D.1, and Walther F. Goebel Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. Volunteers have been immunized with the purified specific antigen of Type V Shigella paradysenteriae (Flexner). The subjects developed a high titer of bacterial agglutinins and mouse-protective antibodies. The agglutinin titer fell moderately after a period of 6 months. The subjects responded fairly well to a small recall dose of the antigen.

2. Two individuals from a group of 10 injected with the specific polysaccharide obtained from Type V organisms responded with an increase in bacterial agglutinins. Mouse-protective antibodies were demonstrable in the one serum tested.

 Submitted on January 16, 1945


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