The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 81, 247-254, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

PASSIVE IMMUNITY TO POLIOMYELITIS IN THE CHIMPANZEE

Howard A. Howe M.D.1 and David Bodian M.D.1

1 From the Poliomyelitis Research Center, Department of Epidemiology, Johns Hopkins University, Baltimore

A series of 6 chimpanzees was inoculated orally with stool from a poliomyelitis patient.

Three of these animals had been given 170 cc. of homologous, hyperimmune monkey serum prior to inoculation, while three were unprotected.

All 6 of the animals were subsequently shown to have poliomyelitis virus in their stools and characteristic lesions in their central nervous systems although none of them developed paralytic poliomyelitis.

All of the immunized animals had demonstrable blood antibody at the time of inoculation although it was present in only one case 30 days later.

 Submitted on November 27, 1944


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