The Journal of Experimental Medicine
3rd Skeletal Biology and Medicine Symposium
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The Journal of Experimental Medicine, Vol 81, 119-135, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMUNITY IN MUMPS : II. THE DEVELOPMENT OF COMPLEMENT-FIXING ANTIBODY AND DERMAL HYPERSENSITIVITY IN HUMAN BEINGS FOLLOWING MUMPS



John F. Enders Ph.D.1, Sidney Cohen M.D.1, and Lewis W. Kane M.D.1

1 From the Department of Bacteriology and Immunology, Harvard Medical School and School of Public Health, Boston

1. A specific antibody, demonstrable by the technique of complement fixation, regularly appears, or increases in concentration, in the sera of human beings during an attack of mumps or during convalescence.

2. Specific dermal hypersensitivity, demonstrable by the injection of heat-inactivated mumps virus, has been shown to develop in 6 human beings after recovery from mumps.

3. Complement-fixing antibody and the hypersensitive state also emerge as a result of clinically inapparent infection with the virus of mumps.

4. These two phenomena are apparently unrelated in respect to immunologic mechanisms.

5. The data presented indicate that the complement fixation test should prove of value both in diagnosis and in the determination of immunity.

6. The skin test for dermal hypersensitivity, on the other hand, becomes positive after recovery and therefore would appear to be useful only as an index of resistance.

 Submitted on September 21, 1944


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