The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 80, 299-307, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS

Elvin A. Kabat Ph.D.1, Hilda Kaiser 1, and Helen Sikorski 1

1 From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

1. Methods for preparing small amounts of Type I meningococcal polysaccharide which are electrophoretically homogeneous and contain only traces of other immunologically reactive material are given.

2. These polysaccharides are very poor antigens in man but in a small number of instances definite amounts of precipitin and protective antibody were formed.

3. The significance of these findings is discussed.

 Submitted on July 26, 1944


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