The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 79, 649-668, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE ETIOLOGY OF PRIMARY ATYPICAL PNEUMONIA : A FILTERABLE AGENT TRANSMISSIBLE TO COTTON RATS, HAMSTERS, AND CHICK EMBRYOS



Monroe D. Eaton M.D.1, Gordon Meiklejohn M.D.1, and William van Herick 1

1 From The Research Laboratory of the California State Department of Public Health, Berkeley

1. A filterable virus from certain cases of primary atypical pneumonia was transmitted to chick embryos by inoculation into the amnion of suspensions of bacteriologically sterile lung tissue or filtered sputum, and three strains were adapted by passage.

2. After intranasal inoculation into cotton rats or hamsters, suspensions of the infected chick embryo tissues produced pulmonary lesions which were similar to those seen after instillation of infective human material.

3. The agent propagated in chick embryos was specifically neutralizable by serum from patients recovered from primary atypical pneumonia and was not neutralized by the acute-phase specimens.

4. Passages of the virus in cotton rats and hamsters gave confusing results because of contamination with latent respiratory agents already present in the animals.

 Submitted on March 30, 1944


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