HETEROGENETIC ANTIBODIES IN ACUTE HEPATITIS

doi:10.1084/jem.79.5.539

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The Journal of Experimental Medicine, Vol 79, 539-557, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

HETEROGENETIC ANTIBODIES IN ACUTE HEPATITIS

Monroe D. Eaton M.D.¹, William D. Murphy M.D.¹, and V. Lee Hanford ¹

¹ From the Research Laboratory of the California State Department of Public Health, Berkeley

A heterogenetic antibody showing fixation of complement withhuman liver and agglutination of sheep erythrocytes was foundin certain cases of acute infective hepatitis.

The antigen concernedin these reactions was apparently heat stable and alcohol soluble.

Differencesfrom other heterogenetic antigen-antibody systems have beennoted.

The possible relation of the heterogenetic antibody toliver damage was considered.

Submitted on February 17, 1944

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