The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 79, 455-461, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE DENATURATION OF ANTIBODY : I. THE ACTION OF UREA ON DIPHTHERIA ANTITOXIN



George G. Wright Ph.D.1

1 From the Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena

Diphtheria antitoxin has been shown to be inactivated in the presence of urea. In 7.5 molar area at pH 7.82 nearly half the activity is destroyed in 24 hours, as measured by the neutralizing power of toxin. The reaction appears to be first order with respect to antitoxin, since the initial rate is independent of the antitoxin concentration, but the rate decreases rapidly with time. Higher or lower pH of the presence of M/10 sodium sulfite increases the antitoxin inactivation.

The meaning of the results is discussed.

 Submitted on December 18, 1943


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