The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 79, 331-339, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

PARA-AMINOBENZOIC ACID PRODUCTION BY STAPHYLOCOCCI

Wesley W. Spink M.D.1, Lemuel D. Wright Ph.D.1, Jean J. Vivino 1, and Helen R. Skeggs 1

1 From the Division of Internal Medicine, University of Minnesota Hospitals and Medical School, Minneapolis, and the Medical-Research Division, Sharp and Dohme, Inc., Glenolden, Pennsylvania

1. Strains of staphylococci produce diazotizable materials which can be converted to a dye, and the intensity of the color reaction can be quantitated in the same manner as p-aminobenzoic acid. The sulfonamide-resistant strains which we have studied produce more diazotizable substance than non-resistant strains.

2. The development of a color by the diazotizable substance can be inhibited by exposing the substance to a soil bacillus (Mirick) specifically adapted to oxidize PABA.

3. The diazotizable substance produced by staphylococci inhibits the anti-staphylococcic action of sodium sulfathiazole to approximately the same degree as equivalent amounts of pure p-aminobenzoic acid.

4. Two microbiological methods for assaying p-aminobenzoic acid were employed for quantitating the amount of this material produced by staphylococci. In general, the sulfonamide-resistant strains produced more p-aminobenzoic acid than the sulfonamide-sensitive strains. The inconstant results obtained with these biological assays are discussed.

 Submitted on December 27, 1943


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