The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 79, 99-114, Copyright, 1944, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE ANTIGENIC COMPOSITION OF GROUP A HEMOLYTIC STREPTOCOCCI : IV. RELATED T BUT DISTINCT M ANTIGENS IN TYPES 15, 17, 19, 23, 30, AND IN TYPES 4, 24, 26, 28, 29, 46. IDENTIFICATION BY SLIDE AGGLUTINATION



Walter A. Stewart M.D., Lieutenant (j.g.)1, Rebecca C. Lancefield Ph.D.1, Armine T. Wilson M.D., Lieutenant1, and Homer F. Swift M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. The occurrence of closely related T antigens in the series composed of types 15, 17, 19, 23, and 30 accounts for most of the cross reactions observed among these types. Similarly T antigens, unrelated to the first series but mutually related, occur in a second series comprising types 4, 24, 26, 28, 29, and 46.

2. Matt variants of each of the eleven types studied possess type-specific M antigens demonstrable either by precipitin or agglutinin reactions.

3. In seven of these types, strains have been encountered which do not possess the T antigen usually associated with the type in question.

4. Procedures are outlined in the appendix for preparing specific antisera for the classification of these types by the slide agglutination technique.

 Submitted on September 29, 1943


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