The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 78, 341-345, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE YIELD OF RABIES VIRUS IN THE CHICK EMBRYO

Björn Sigurdsson M.D.1

1 From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

Rabies virus was inoculated intracerebrally in 8 day old chick embryos and the virus activity of pools of embryos titered after incubation at 35–36°C. for different lengths of time. The virus reached a titer of 10–5.5 to 10–6.5 in 5 to to 6 days and remained at a rather constant level until the 9th day of the infection. The report by Kligler and Bernkopf that rabies virus will invade the very young embryo after inoculation on the chorioallantoic membrane was confirmed.

Submitted on July 16, 1943


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