The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 78, 333-339, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

PRODUCTION OF A SCURVY-LIKE CONDITION BY FEEDING OF A COMPOUND STRUCTURALLY RELATED TO ASCORBIC ACID

D. W. Woolley Ph.D.1 and L. O. Krampitz Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

The feeding of glucoascorbic acid, an analog of ascorbic acid, to mice and cotton rats caused the production of a condition exhibiting many of the changes characteristic of scurvy as seen in susceptible species.

The condition was not prevented or cured by ascorbic acid, but was cured by removal of the glucoascorbic acid from the ration.

The condition was produced in mice fed a highly purified ration. It was not produced in mice fed a natural ration. The presence of a substance in certain plant products which prevented the production of the condition was demonstrated.

 Submitted on July 3, 1943


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