The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 78, 305-313, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON HERPETIC INFECTION IN MICE : I. PASSIVE PROTECTION AGAINST VIRUS INOCULATED INTRANASALLY



George Packer Berry M.D.1 and Howard B. Slavin M.D.1

1 From the Departments of Bacteriology and Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Passive immunity, naturally acquired from immune mothers or artificially induced through the administration of immune rabbit serum, conferred on suckling mice of the albino Swiss strain a high degree of resistance against herpetic infection following the intranasal instillation of the virus. Antibodies, which could be readily demonstrated in the blood of 2-week-old mice, were received by the offspring of immune mothers primarily by the mammary route. Naturally acquired immunity declined rapidly when suckling was interrupted. Herpes virus was not recovered from the fetuses of either immune or infected, non-immune mothers.

Submitted on May 1, 1943


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