The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 78, 161-168, Copyright, 1943, by The Rockefeller Institute for Medical Research New York


ARTICLE

THE MULTIPLICATION OF BACTERIOPHAGE IN VIVO AND ITS PROTECTIVE EFFECT AGAINST AN EXPERIMENTAL INFECTION WITH SHIGELLA DYSENTERIAE

René J. Dubos Ph.D.1, June Hookey Straus 1, and Cynthia Pierce Ph.D.1

1 From the Department of Comparative Pathology and Tropical Medicine, Schools of Medicine and Public Health, Harvard University, Boston

1. Anti-Shiga bacteriophage injected into the general circulation can multiply in the brain of mice infected intracerebrally with Shigella dysenteriae.

2. Under proper conditions, the injection of active bacteriophage into the general circulation can protect mice against an otherwise fatal intracerebral infection with Shigella dysenteriae.

3. The protection so induced appears to depend upon the early establishment of a high bacteriophage level in the infected animal.

Submitted on May 22, 1943


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