The Journal of Experimental Medicine
PBL InterferonSource
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 401K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, H. M.
Right arrow Articles by Sprunt, D. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Taylor, H. M.
Right arrow Articles by Sprunt, D. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 78, 91-97, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES

Haywood M. Taylor Ph.D.1 and Douglas H. Sprunt M.D.1

1 From the Departments of Biochemistry and Pathology, Duke University School of Medicine, Durham, North Carolina

Experiments are described in which it is shown that the estrogenic hormone (alpha-estradiol propionate) increases the amount of extracellular fluid in the skin. Since previous work showed that this hormone increases resistance of rabbits to vaccinia virus, it is suggested that the increased resistance is the result of increased fluid in the tissues.

In further test of this thesis, experiments were performed in which the extracellular fluid in the skin was increased by the intraperitoneal injection of a salt solution known to increase the hydration of the tissues. Under these conditions it was found that the spread of India ink in the skin, as well as susceptibility to viral infection, was decreased in the same magnitude as obtains when the animals are treated with estrogenic hormone. The identity of effects under the two sets of circumstances seems to warrant the conclusion that in both instances the spread of India ink and decreased susceptibility to vaccinia are due to the common factor of increased volume of the extracellular fluid.

 Submitted on April 5, 1943


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS