The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 77, 435-449, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE IMMUNOLOGICAL PROPERTIES OF THE HETEROPHILE ANTIGEN AND SOMATIC POLYSACCHARIDE OF PNEUMOCOCCUS

Walther F. Goebel Ph.D.1 and Mark H. Adams Ph.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. The lipocarbohydrate or F polysaccharide derived from a rough variant of Type I pneumococcus (I R) is antigenic in rabbits and gives rise to precipitins and sheep cell hemolysins. The somatic or C carbohydrate on the other hand is not antigenic.

2. Antisera for the rough variant of Type 1 pneumococcus contain also bacterial agglutinins immunologically unrelated to the C and F precipitins and the heterophile antibody.

3. A study has been made of the quantitative precipitin reaction of the C and F polysaccharides in the serum of rabbits immunized with the IR pneumococcus clarifying certain of these relationships.

 Submitted on February 1, 1943


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