The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 77, 345-354, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

ISOLATION OF CHROMATIN THREADS FROM THE RESTING NUCLEUS OF LEUKEMIC CELLS

Albert Claude M.D.1 and James S. Potter Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor

1. A method for the separation of chromatin threads from the resting nucleus of leukemic cells has been described.

2. The isolation of the chromatin strands was accomplished by purely mechanical means, and the separation, including extraction and purification in the centrifuge, required only about 1 hour.

3. Evidence is presented to show that the chromatin strands are morphologically related to the chromosomes, if not identical.

4. It seems probable that, by the present technique, chromatin strands can be obtained from different mammalian tissues for direct microscopical examination and biochemical analysis.

 Submitted on December 24, 1942


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