The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 76, 579-585, Copyright, 1942, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE METABOLISM OF THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL POLIOMYELITIS

E. Racker M.D.1 and Herman Kabat M.D.1

1 From the Anderson Institute for Biological Research and the Department of Physiology, University of Minnesota, Minneapolis

1. During paralysis, the brain of the mouse infected with poliomyelitis virus shows on test after mincing a decrease in anaerobic glycolysis with no significant change in oxygen utilization. The decrease in anaerobic glycolysis varies from 5 per cent to 50 per cent.

2. Sodium fluoride produces a greater inhibition of anaerobic glycolysis in normal than in poliomyelitic brain.

3. Dehydrogenase activity is higher for poliomyelitis-infected brain without added substrate. This difference from normal disappears when substrates are added.

4. The ratio of

See PDF for Equation

for the sliced motor cortex is higher than

for sliced visual cortex of the dog and cat.

5. The oxygen consumption of the anterior horn of the sliced spinal cord of dog and cat is much less than that of the cerebral cortex.

6. The findings are in keeping with the view that, at a certain stage of the infection, the nerve cells may be reversibly injured but not yet destroyed by the virus.

 Submitted on August 13, 1942


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