The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 75, 315-322, Copyright, 1942, by The Rockefeller Institute for Medical Research New York

ARTICLE

HUMAN ALLERGY TO MAMMALIAN SERA

Frank A. Simon M.D.1

1 From the Department of Medicine, University of Louisville School of Medicine, Louisville

Four patients allergic to many mammalian sera were found to have circulating, skin-sensitizing antibodies for these sera. A study of these antibodies by in vitro neutralization and subsequent local passive transfer showed that, in the case of each patient, one particular mammalian serum neutralized antibodies for all sera whereas other mammalian sera neutralized antibodies for themselves alone or for themselves plus one or several additional sera but not for all sera. The possibility of multiple common allergenic determinants in mammalian sera is discussed.

Submitted on October 30, 1941


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