The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 75, 191-195, Copyright, 1942, by The Rockefeller Institute for Medical Research New York

ARTICLE

LIVER DAMAGE AND URINARY EXCRETION OF SULFATE IN RATS FED l-CYSTINE, dl-METHIONINE, AND CYSTEIC ACID

David P. Earle Jr. M.D.1 and Forrest E. Kendall Ph.D.1

1 From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

1. Rats fed l-cystine at excessive levels excrete large amounts of sulfate sulfur in the urine and develop liver necrosis and cirrhosis.

2. Rats fed dl-methionine at excessive levels excrete large amounts of sulfate sulfur, but do not develop liver necrosis and cirrhosis.

3. Rats fed cysteic acid at high levels excrete relatively small amounts of sulfate, but do develop liver necrosis and cirrhosis.

4. In conclusion, there is no apparent correlation between the amount of sulfate formed and the development of liver damage in rats fed l-cystine, dl-methionine, and cysteic acids.

 Submitted on October 31, 1941


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