The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 75, 77-92, Copyright, 1942, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS

Edward C. Curnen M.D.1 and Colin M. MacLeod M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. Sulfapyridine, administered to rabbits during the period of developing immunity after a single intravenous injection of heat-killed Pneumococcus Type I, exerted no influence upon the immune response.

2. Active immunity as indicated by increased resistance to homologous intradermal infection was present 48 hours after the immunizing injection and 2 days before circulating type specific antibodies were detectable.

3. Of the serological techniques employed for the detection of circulating antibody the mouse protective test yielded the highest percentage of positive results followed in order by tests for type specific agglutinins and precipitins, the latter being least satisfactory for the detection of small amounts of antibody.

 Submitted on October 20, 1941


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