The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 766K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baker, Z.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Baker, Z.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 74, 621-637, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

INHIBITION BY PHOSPHOLIPIDS OF THE ACTION OF SYNTHETIC DETERGENTS ON BACTERIA

Zelma Baker Ph.D.1, R. W. Harrison Ph.D.1, Benjamin F. Miller M.D.1, and With the Technical Assistance of Robert Wexler

1 From the Walter G. Zoller Memorial Dental Clinic, the Department of Bacteriology and Parasitology, and the Department of Medicine, The University of Chicago, Chicago

1. Lecithin, cephalin, and sphingomyelin prevent the inhibition of bacterial metabolism which is caused by synthetic anionic and cationic detergents. The phospholipids must be added either before or simultaneously with the detergent. Addition after the detergent is without effect. Bacteria still exhibit this phenomenon after they have been exposed to the phospholipid and thoroughly washed.

2. A similar action of the phospholipids has been demonstrated towards the bactericidal compounds isolated by Dubos and Hoogerheide from soil bacteria. There is very little effect with bactericidal mercury compounds.

3. The effect of lecithin against the bactericidal action of synthetic detergents was also determined. It was found that germicidal quantities of the detergents were not effective in the presence of the phospholipids.

 Submitted on August 22, 1941


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS