The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 74, 611-620, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE BACTERICIDAL ACTION OF SYNTHETIC DETERGENTS

Zelma Baker Ph.D.1, R. W. Harrison Ph.D.1, Benjamin F. Miller M.D.1, and With the Technical Assistance of Robert Wexler

1 From the Walter G. Zoller Memorial Dental Clinic, the Department of Bacteriology and Parasitology, and the Department of Medicine, The University of Chicago, Chicago

1. The bactericidal action of a number of anionic and cationic synthetic detergents on four Gram-positive and three Gram-negative bacteria has been investigated.

2. Cationic detergents, as a group, were found to exhibit marked bactericidal effects on Gram-positive microorganisms and somewhat less pronounced action on Gram-negative organisms.

3. The anionic detergents were germicidal only against the Gram-positive organisms, and they were considerably less effective than the cationic compounds. Of the anionic detergents, the most active one was an alkyl sulfate derived from a branched-chain, secondary alcohol.

4. Correlations between bactericidal action and inhibition of bacterial metabolism, and also between bactericidal action and chemical structure of the detergents are discussed.

 Submitted on August 22, 1941


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