The Journal of Experimental Medicine
Randox
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fekete, E.
Right arrow Articles by Little, C. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Fekete, E.
Right arrow Articles by Little, C. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 74, 1-8, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

HISTOLOGICAL CHANGES FOLLOWING OVARIECTOMY IN MICE : I. dba HIGH TUMOR STRAIN



Elizabeth Fekete 1, George Woolley Ph.D.1, and C. C. Little Sc.D.1

1 From the Roscoe B. Jackson Memorial Laboratory, Bar Harbor

1. In dba mice ovariectomized at birth the vagina, uterus, and mammary glands showed a gradual recovery from the castrate state, and finally reached the stage which they presumably can attain only under the influence of estrogenic hormones. Tumors of the mammary glands developed in 37 animals, of 75 examined, between the ages of 14 and 28 months (3 adenomas and 34 carcinomas).

2. As ovarian regeneration had not taken place the probability that estrogen originated in some other organ in the absence of the ovaries is suggested.

3. The consistent nodular hyperplasia of the suprarenal cortex and close morphological similarity of cells of these nodules to lutein-like cells of the ovaries points to the abnormal suprarenals as possible sources of the estrogenic hormones.

 Submitted on April 15, 1941


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS