The Journal of Experimental Medicine
PBL InterferonSource
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 1378K)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sabin, A. B.
Right arrow Articles by Ward, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Sabin, A. B.
Right arrow Articles by Ward, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 73, 771-793, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE NATURAL HISTORY OF HUMAN POLIOMYELITIS : I. DISTRIBUTION OF VIRUS IN NERVOUS AND NON-NERVOUS TISSUES



Albert B. Sabin M.D.1 and Robert Ward M.D.1

1 From The Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati

1. Studies on a large number of tissues obtained from fatal cases of human poliomyelitis have revealed that the virus is distributed predominantly in two systems: (a) certain regions of the nervous system, and (b) the alimentary tract.

2. Poliomyelitis virus was demonstrated in the walls of the pharynx, ileum, and only once in those of the descending colon, while the contents of the descending colon regularly contained the virus.

3. The presence of virus in the walls of the alimentary tract appears to be the result neither of generalized dissemination of the virus nor of secondary centrifugal spread, but rather that of primary localization or portal of entry.

4. In the absence of evidence of any demonstrable centrifugal spread to peripheral collections of nerve cells (e.g., in the superior cervical sympathetic ganglia, suprarenals, salivary glands), the presence of virus in the abdominal sympathetic plexus of one case may be indicative of at least one pathway of centripetal virus progression.

5. The absence of demonstrable virus in the nasal mucosa, olfactory bulbs, and anterior perforated substance suggests that neither the upper respiratory tract nor the olfactory pathway were affected in the cases of human poliomyelitis studied in the present investigation.

 Submitted on March 6, 1941


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS