The Journal of Experimental Medicine, Vol 73, 487-492,
Copyright, 1941, by The Rockefeller Institute for Medical Research New York
A NEW GROWTH FACTOR REQUIRED BY CERTAIN HEMOLYTIC STREPTOCOCCI
D. W. Woolley Ph.D.1
1 From the Laboratories of The Rockefeller Institute for Medical Research
A new factor essential for the growth of hemolytic streptococci of Lancefield's group A has been demonstrated. It has not been possible to identify this factor with any other known growth factor. The active substance occurred in liver as a water-soluble, alcohol-insoluble, non-dialyzable material. It could be rendered dialyzable by treatment in strong alcohol with HCl, but not by many less drastic procedures.
The most active concentrates prepared gave a maximal effect when approximately 10 gamma per cc. were added.
Submitted on December 20, 1940