The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 73, 335-355, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

A COMPLEX VACCINE AGAINST INFLUENZA A VIRUS : QUANTITATIVE ANALYSIS OF THE ANTIBODY RESPONSE PRODUCED IN MAN



Frank L. Horsfall Jr. M.D.1, Edwin H. Lennette M.D.1, and Elsmere R. Rickard M.D.1

1 From the Laboratories of the International Health Division of The Rockefeller Foundation, New York

A quantitative study of the antigenicity of various vaccines containing influenza A virus has been made in human beings. A complex vaccine prepared from chick embryos inoculated with both influenza A virus and the X strain of canine distemper virus was found to be more effective than other vaccines in stimulating the production of neutralizing antibodies against the former virus. The increased antibody levels which resulted from the administration of this vaccine remained almost unaltered for at least 5 months.

Submitted on November 14, 1940


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