The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 73, 1-5, Copyright, 1941, by The Rockefeller Institute for Medical Research New York

ARTICLE

A STUDY OF QUANTITATIVE CHANGES OF THE SHOPE RABBIT PAPILLOMA VIRUS AT THE SITE OF INOCULATION IN THE SKIN OF THE COTTONTAIL AND DOMESTIC RABBIT

Thorolf Packalén M.D.1

1 From the Department of Immunology, Laboratories of Immunology and Filterable Viruses, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore

By excising after varying intervals the site of inoculation of the rabbit skin injected intracutaneously with the Shope papilloma virus and titrating its virus content, it has been shown that demonstrable active virus disappears from the skin within approximately 24 hours. The disappearance of most of the virus within such a short time as 15 to 60 minutes makes a transportation of virus from the site of inoculation as a responsible factor unlikely. The rate of disappearance seems to be the same both in the domestic and in the cottontail rabbit.

Submitted on October 1, 1940


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