The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 72, 717-728, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA

Thomas Francis Jr. M.D.1 and Alice E. Moore 1

1 From the Department of Bacteriology, College of Medicine, New York University, New York

The demonstration by Stuart-Harris that the W.S. strain of epidemic influenza virus can induce a fatal nervous disease in mice has been confirmed.

In contrast, however, no previous period of adaptation to chick embryonic brain was required. By serial brain to brain passages in mice originally inoculated with the virus cultivated in the usual chick embryo culture medium a fatal disease, essentially meningeal in character, is produced.

The Melbourne strain has been similarly enhanced while other strains have failed to reveal any neurotropic tendencies.

The evidence indicates that the neurotropic characteristic is present in the two strains as an inherent quality which is quantitatively heightened and does not represent the acquisition of a property not previously present.

 Submitted on August 12, 1940


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