The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 72, 361-366, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VIII. SENSITIZATION TO PICRIC ACID; SUBSIDIARY AGENTS AND MODE OF SENSITIZATION



K. Landsteiner M.D.1 and A. A. Di Somma Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Sensitization of guinea pigs to picric acid was obtained by application of oil solutions to the skin, preferably on inflamed sites or by treatment with a compound of picric acid with n-butyl-p-aminobenzoate. The lesions obtained in sensitive animals on superficial administration bore resemblance to human eczema.

It seems probable that picric acid sensitization is an instance where a substance does not sensitize directly but after conversion into a more reactive compound, a principle which should be of wider application to instances where the original substance does not readily form conjugates.

 Submitted on June 26, 1940


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