The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 72, 91-97, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RELATIONSHIP OF SULFAPYRIDINE, NICOTINIC ACID, AND COENZYMES TO THE GROWTH OF STAPHYLOCOCCUS AUREUS

Randolph West M.D.1 and Alvin F. Coburn M.D.1

1 From the Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York

Our studies indicate that sulfapyridine modifies the normal metabolism of a bacterium.

Coenzymes inhibit the effect of sulfapyridine on the growth of staphylococcus in Knight's medium.

Nicotinic acid does not interfere with the action of sulfapyridine under the same conditions.

The possible relation of sulfapyridine, nicotinic acid, and coenzymes in relation to bacterial growth is discussed.

 Submitted on May 2, 1940


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