The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 72, 69-77, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

ENCEPHALOMYELITIS OF MICE : II. A METHOD FOR THE MEASUREMENT OF VIRUS ACTIVITY



Sven Gard M.D.1

1 From the Laboratories of the International Health Division of The Rockefeller Foundation, New York

In a study of mouse encephalomyelitis the following observations were made:—

1. A definite relationship exists between the amount of virus inoculated intracerebrally and the length of the incubation period.

2. The reciprocal of the incubation period was found to be approximately proportionate to the logarithm of the amount of virus inoculated. The relationship can, therefore, be given a simple mathematical form.

3. This fact provides a basis for a new method for measurement of the activity of mouse encephalomyelitis virus.

 Submitted on April 11, 1940


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