The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 71, 603-618, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)

Lester S. King M.D.1

1 From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75°C., acting for 15 minutes. The agent is digested by pepsin. It exhibits a slight degree of sedimentation with the air-driven centrifuge. It is non-dialyzable. It is precipitated from solution (pH 7.4) by ammonium sulfate, over a range of 0.4 to 0.8 saturation. These findings all suggest that the agent is a protein. No immunological reactions could be elicited.

Submitted on February 19, 1940


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