The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 71, 569-583, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA

G. H. Whipple M.D.1 and F. S. Robscheit-Robbins Ph.D.1

1 From the Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded.

Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase hemoglobin output on the average 23 to 25 gm. above the control level. This reaction amounts to 25 to 30 per cent of the new hemoglobin produced by the feeding of 300 gm. liver daily for 2 weeks—a standard liver test.

Alanine, valine, isoleucine, and arginine in the same dosage increase the hemoglobin output on the average 13 to 17 gm. per 2 weeks over the control level.

Leucine, methionine, lysine, tryptophane, and tyrosine fall in a middle group with hemoglobin output of about 20 gm.

Isovaleric acid, ß-hydroxybutyric acid, glutaric acid, and asparagine have shown positive effects and the butyrate is unusually potent for hemoglobin production (Table 2).

The isomeric and dl-synthetic forms of the amino acids are as effectively utilized in this reaction as are the natural forms.

 Submitted on February 22, 1940


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