The Journal of Experimental Medicine
Torrey Pines Biolabs
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The Journal of Experimental Medicine, Vol 71, 445-454, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

ON CROSS REACTIONS OF EGG ALBUMIN SERA

K. Landsteiner M.D.1 and J. van der Scheer 1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Experiments are presented on the cross reactions of hen egg albumin immune sera with egg albumins of other species by means of exhaustion with heterologous proteins and by inhibition tests. From the results it can be concluded that the sera contain multiple, qualitatively distinct antibodies. For this, two not mutually exclusive explanations come into consideration: the presence in proteins of a number of different, perhaps similar, complex determinants, and the fact, established by previous results, that one antigenic grouping can call forth the formation of diverse antibodies.

It is inferred that cross reactions between proteins of kindred species are ascribable, in general, to similarity in determinant structures, and not to the distribution of identical determinant groups among the related proteins.

 Submitted on January 3, 1940


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