The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 71, 237-245, Copyright, 1940, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS



K. Landsteiner M.D.1 and M. W. Chase Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A method has been described by which sensitization to a simple chemical, picryl chloride (2:4:6 trinitrochlorobenzene), can be satisfactorily attained by means of intraperitoneal injection of the compound when killed tubercle bacilli suspended in paraffin oil were used as adjuvant. Sensitivity of the contact dermatitis type results therefrom. It follows that although skin sensitization of this type is most easily obtained by dermal application this route of administration is no necessary condition for such sensitivity.

Submitted on November 30, 1939


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