The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 70, 499-510, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE PATHOGENESIS OF MENINGOCOCCUS MENINGITIS IN THE CHICK EMBRYO

G. John Buddingh M.D.1 and Alice D. Polk 1

1 From the Department of Pathology, Vanderbilt University Medical School, Nashville

1. A microscopic and bacteriological analysis of the meningitis produced in the chick embryo following inoculation of meningococci into the body wall or into the amniotic cavity indicates that the meninges are invaded by way of the blood stream.

2. There is no indication that a direct extension of the infection by way of the middle ear, the cranial sinuses or the pia-arachnoid sheath of the olfactory nerves to the meninges takes place.

 Submitted on August 6, 1939


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