The Journal of Experimental Medicine, Vol 70, 387-397,
Copyright, 1939, by The Rockefeller Institute for Medical Research New York
THE SPECIFICITY OF KERATEINE DERIVATIVES
L. Pillemer Ph.D.1,
E. E. Ecker Ph.D.1, and
E. W. Martiensen 1
1 From the Institute of Pathology and the University Hospitals, Western Reserve University, Cleveland
Carboxymethyl, 
-carboxyethyl-, -carboxy-n-propyl-, -carboxyisopropyl-, -carboxy-n-butyl, -carboxyisobutyl, -carboxyamyl-, benzyl-, and ß-phenylethylkeratemes were prepared from the parent protein, reduced keratin or kerateine. Chemical analysis disclosed that the various compounds differed in their isoelectric points and solubilities depending on the nature of the substituent group introduced. In general, it was found that in so far as could be determined, nearly all of the available sulfhydryl groups were substituted, while no detectable substitution of the free amino groups of the proteins occurred.
The results of the serologic studies revealed that the kerateine derivatives acquired a new immunologie character dependent on the nature of the introduced determinant group. Inhibition tests confirmed the results obtained. Evidence was also produced to show that the grouping
See PDF for structure
may play a rôle in some of the reactions observed.
Submitted on July 12, 1939
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