The Journal of Experimental Medicine
MBL International Tel: 800.200.5459 CLICK HERE
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seastone, C. V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Seastone, C. V.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 70, 347-359, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

HEMOLYTIC STREPTOCOCCUS LYMPHADENITIS IN GUINEA PIGS

C. V. Seastone M.D.1

1 From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

A group of guinea pigs carrying a chronic streptococcus cervical lymphadenitis has been studied. The chronic disease may be transmitted with pure cultures of streptococci isolated from the naturally occurring abscesses. Its probable mode of transmission under natural conditions was shown to be the ingestion of the infective agent.

The spontaneous appearance of an acutely fatal variant was observed. Infection with the chronic strains protected animals against the highly virulent strain. Such immunity could not be passively transferred to either mice or guinea pigs, nor could any opsonizing, precipitating, or bactericidal antibody be associated with it. The presence of allergy could not be correlated with this immunity.

The dissociation of the chronic and acute strains was investigated and non-invasive phases isolated. No precipitin reaction attributable to an antigenic virulence factor could be demonstrated. No protection was obtained with vaccines or aggressins.

 Submitted on June 30, 1939


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS