The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 70, 223-230, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE PRODUCTION OF KIDNEY ANTIBODIES BY INJECTION OF HOMOLOGOUS KIDNEY PLUS BACTERIAL TOXINS

Francis F. Schwentker M.D.1 and Frank C. Comploier 1

1 From the Sydenham Hospital for Communicable Diseases, Baltimore City Health Department, Baltimore

Rabbits injected with emulsions of homologous kidney to which staphylcoccus or streptococcus toxins had been added produced complement fixing antibodies which reacted with both rabbit kidney and brain. By absorption tests it was demonstrated that the sera contained at least two antibodies, one specific for kidney, the other non-specific. Similar kidney antibodies were found in the blood of a majority of patients with scarlet fever but in only a few normal persons. The possibility that a similar or related antibody may be concerned in the etiology of scarlatinal nephritis is discussed.

Submitted on April 6, 1939


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