The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 70, 209-222, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED



Frank L. Horsfall Jr. M.D.1

1 From the Laboratories of the International Health Division of The Rockefeller Foundation, New York

A linear relationship exists between the logarithm of the quantity of epidemic influenza virus neutralized and the logarithm of the quantity of antiserum which is capable of achieving this result. This relationship is the same for the serum of a ferret convalescent from experimental influenza as for the serum of a rabbit immunized with the virus. By means of the linear relationship between virus and antiserum it is possible to determine a fixed, rather than a relative, value for the neutralizing capacity of a serum.

Submitted on June 14, 1939


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