The Journal of Experimental Medicine, Vol 70, 185-192,
Copyright, 1939, by The Rockefeller Institute for Medical Research New York
HEPATIC INJURY ON A NUTRITIONAL BASIS IN RATS
Paul György M.D.1 and
Harry Goldblatt M.D.1
1 From the Babies and Childrens Hospital, the Institute of Pathology, and the Departments of Pediatrics and Pathology, School of Medicine, Western Reserve University, Cleveland
In forty-eight rats kept on a basal diet deficient in the vitamin B complex and supplemented with vitamin B1 and riboflavin or with vitamin B1, riboflavin and vitamin B6, various pathological changes in the liver were observed. These changes were characterized mainly by parenchymatous and fatty degeneration, focal and massive necrosis, hyperemia and hernorrhage and, in some of the rats, by perilobular and condensation fibrosis. Addition of yeast or Peters' eluate (yeast extract) regularly prevented this hepatic injury. On the basis of the evidence obtained, it is assumed that the liver changes are of nutritional origin and should be correlated to deficiency of a part of the vitamin B2 complex.
Submitted on May 12, 1939
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